– Anxiety
– Schizophrenia
– Other Indications as Clinically Justified
References
1. Therapeutic Goods Administration (TGA). “Guidance for the use of medicinal cannabis in the treatment of chronic non-cancer pain in Australia”. January 25, 2024. https://www.tga.gov.au/medicinal-cannabis-guidance-documents.
2.Bergamaschi MM, et al. Cannabidiol reduces the anxiety induced by simulated public speaking in treatment naïve social phobia patients. Neuropsychopharmacology. 2011;36(6):1219-26.
THESE TITRATION MODELS SERVE AS AN EXAMPLE AND MUST BE ADAPTED TO EACH PATIENT
Days
Morning dose
(mL of oral solution)
Evening dose
(mL of oral solution)
Total daily dose
(mL of oral solution)
Total CBD daily dose
(mg)
1–2*
0.25
0.25
0.5
50
3–4
0.50
0.50
1
100
5–6
0.75
0.75
1.5
150
7–8
1
1
2
200
9–10
1.5
1.5
3
300
Titration scheme and practical dosing recommendations:
*Ideally, the administration should start with an evening dose to limit adverse events and encourage the development of tolerance.
References
1. MacCallum CA, Russo EB. Practical considerations in medical cannabis administration and dosing. EwoRean Journal of Internal Medicine. 2018; 49: 12-19.